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We will never ask you to trust us simply because we say we're different. We earn that through thoughtful formulation, honest communication and claims we can defend.
Because understanding changes skincare.
Not a generic routine. Not another list of trending ingredients. This is the guide I wish had existed when I started dealing with acne at ten years old - and everything I now know from thirty years of treating it clinically.
Based on my published book Breakout and thirty-seven years of clinical practice. Everything in here is the truth - not what I think you want to hear.
Before we begin
I want to tell you something before you read a single word of advice in this guide.
I have been where you are. I had my first pimple at ten years old. By the time I was a teenager, I was refusing to let my mother photograph me at family events. A boy in my art class did a portrait of me and drew oil wells on my face. I stood at the school bus stop rubbing my face with the fabric of my shirt to stop myself from scratching until it bled.
I became a Nurse Practitioner. I spent thirty years treating skin in clinical settings. I became an Adjunct Associate Professor. And for a long time, even with all of that knowledge, I still couldn't fix my own skin.
Not because I wasn't trying hard enough. Because I was approaching it the wrong way - the way the entire industry approaches it. Treating the breakout. Not the barrier underneath it.
That realisation is the foundation of everything in this guide. It's also the foundation of Science Skincare. And it's why I sit down one on one with people whose skin I genuinely want to help - not to sell them something, but to give them an honest answer about what's actually going on.
Work through this guide honestly. The skin profile section will help you identify what type of acne you're dealing with and what it actually needs. The ingredient section will tell you what works and what doesn't. The timeline will tell you what to expect - including the parts that are uncomfortable but important to know.
And if you want to talk it through with me personally, the information is at the end.
Truth. Trust. Time. That's what this is built on.
With love,
Elissa
Elissa O'Keefe
Nurse Practitioner · Founder, Science Skincare
Acne is not one thing. The approach that works for comedonal acne (blackheads and whiteheads) is completely different from the approach for hormonal cystic acne. Most people are treating the wrong type - or treating multiple types as if they're one. Let's sort that out.
Look at your skin now and identify what you can see.
Location tells us a lot about cause.
Select the one that resonates most.
Based on what you've identified above, find the profile below that sounds most like your skin. Read all of it - including what to do and what to stop. Many people have overlapping profiles; that's normal.
"I had a patient with hormonal acne who had seen four different doctors and been told it would resolve after her twenties. She was 38 when she came to see me. That advice is wrong. Hormonal acne in adult women is common, treatable, and deserves proper care." - Elissa
"If your skin is tight, red, reactive, and nothing seems to work - please hear this: that's not your skin being difficult. That's your skin asking you to stop stripping it." - Elissa
"Stress-triggered acne is the one my patients feel most ashamed of - as if they're causing their own skin problems by not being calm enough. You are not. Your skin is doing what skin does under physiological stress." - Elissa
"Comedonal acne is the type most dismissed - 'it's just blackheads' - but it's also the type that responds best to the right early treatment. Get onto it properly and many people don't develop inflammatory acne at all." - Elissa
"If you've been dealing with this for years and your skin falls into multiple categories - this is exactly who I designed the Breakout Collection for. And it's exactly the conversation I have in a skin consult." - Elissa
This is where most people get lost. The skincare industry lists hundreds of ingredients with equally bold claims. Here is what the clinical evidence actually says - and what I use in Science Skincare because it works, not because it photographs well.
The gold standard for acne - clinically the most effective non-prescription ingredient available. Vitamin A prevents the follicular clumping of skin cells that creates comedones, reduces C. acnes bacteria, regulates oil production, and drives cell turnover to fade post-inflammatory marks.
What most people get wrong: concentration. Most over-the-counter retinol products sit at concentrations too low to drive real cell renewal. The most bioavailable and least irritating forms are retinaldehyde and retinyl palmitate - which is why these are in Science Skincare rather than basic retinol.
On the purge: initial increase in breakouts in weeks 1–3 is normal and a sign that the product is working. Most people stop here. Most people who stop here miss the result that arrives at week four. Pairing with niacinamide significantly reduces the adjustment response.
Pregnancy: The forms used in Science Skincare (retinaldehyde and retinyl palmitate) are not detectable in the bloodstream when applied topically. If in any doubt, consult your midwife or doctor.
One of the most versatile ingredients in acne skincare. Niacinamide repairs the skin barrier, regulates sebum production, reduces redness and inflammation, minimises pore appearance, and helps fade post-inflammatory pigmentation.
Why it's particularly important for acne-prone skin: it does all of this without disrupting the barrier - which means it can be used alongside active ingredients like Vitamin A to buffer their adjustment response. It is the ingredient that makes other ingredients work better.
Look for it at 2–5% in a formulation. Below that, the concentration is unlikely to have meaningful clinical effect.
The only beta hydroxy acid used in skincare, and the most important exfoliant for acne-prone skin. Salicylic acid is oil-soluble - which means it can penetrate inside the pore and dissolve the sebum that forms blackheads and congestion. AHAs (mandelic, lactic acid) work at the surface; salicylic acid works inside the follicle.
This distinction matters enormously. Surface exfoliants address what you can see; salicylic acid addresses what's forming underneath. Any acne routine without it is missing the step that prevents congestion from forming in the first place.
Concentration 0.5%–2% for daily use. Higher concentrations used in professional peels.
Alpha hydroxy acids exfoliate the skin's surface by loosening the connections between dead skin cells, promoting their removal, and stimulating the skin to produce its own natural moisturising factors. They also help fade superficial post-inflammatory hyperpigmentation (brown marks).
Use alongside BHA, not instead of it. They address different levels - AHA at the surface, BHA inside the pore.
Sun sensitivity: AHAs increase UV sensitivity. Sun protection is not optional when you're using them. Every morning, regardless of weather.
Vitamin C is a powerful antioxidant that protects the skin from oxidative stress (which worsens acne-related inflammation), prevents sebum oxidation, helps fade post-inflammatory hyperpigmentation, and boosts collagen production to support healing.
The most potent natural source of Vitamin C is Australia's Kakadu Plum - it contains the highest known natural Vitamin C concentration of any food on earth. This is one of the reasons Science Skincare uses Australian botanicals as part of the formulation, not as decoration.
Combined with physical sun protection, Vitamin C provides significantly better protection against UV-induced damage - which matters because sun exposure worsens brown scarring.
Manuka honey is one of the only topical agents with a robust evidence base for both antimicrobial and wound healing activity. Studies have shown it inhibits the growth of C. acnes bacteria (the organism responsible for acne) as well as Staphylococcus aureus.
The active components - methylglyoxal (MGO) and hydrogen peroxide - provide the antibacterial effect, while the honey itself supports the skin's natural healing response and reduces inflammation.
Why this matters in a system: most antibacterial acne treatments are aggressive and disrupt the skin microbiome. Manuka honey provides antibacterial activity while simultaneously supporting barrier health - the combination that makes it genuinely useful rather than just trending.
Benzoyl peroxide (BP) is a widely used, safe, and effective acne therapy. It kills C. acnes bacteria and is one of the few treatments where bacterial resistance has never been reported - making it useful alongside antibiotics to prevent resistance developing.
Useful as a spot treatment for pustular acne. Less useful as the foundation of a routine because of its drying, barrier-disrupting effect at higher concentrations.
Start low (2.5%) and work up. Bleaches hair, clothing, and bed linen. Avoid applying at the same time as tretinoin (prescription Vitamin A) as it reduces its efficacy.
The honest answer: diets high in sugar (including fast food, alcohol, and most packaged foods) and consuming more than one serving of dairy per day have both been linked to increased breakouts in clinical research.
That is the extent of the dietary evidence. Every other dietary claim - elimination diets, specific foods, supplements, detox protocols - is not backed by good quality research. Twenty-four years of elimination diets, as one reader of my book told me, is not an unusual experience. And it rarely works.
My advice: reduce sugar and dairy moderately. Add probiotic foods (yoghurt, kefir, kimchi) to support gut health. See a nutritionist if you want to go further - not a blog post or TikTok account. Don't put yourself on a restrictive diet without professional guidance; the nutritional consequences of dramatically limiting food groups can affect bone health and overall wellbeing.
Hydroquinone has long been considered the "gold standard" for skin lightening and is widely used for post-inflammatory hyperpigmentation (brown acne marks).
I no longer recommend it. University of Texas researchers have found that hydroquinone exposure is linked to a significant increase in skin cancers, including melanoma. Additionally, in melanin-rich skin, it can cause exogenous ochronosis - a greyish discolouration that is extremely difficult to improve.
There are safer and effective alternatives: Vitamin C, azelaic acid, niacinamide, and peptides (particularly Tetrapeptide-30) all address post-inflammatory pigmentation without these risks.
Scrubs: The physical abrasion of facial scrubs disrupts the skin barrier and causes inflammation - worsening the very condition they're marketed to treat. The idea that scrubbing opens comedones is not supported by evidence. If you like the feeling of a scrub, monthly microdermabrasion by a professional is a more effective and less damaging version of the same concept.
Pore strips: These remove only the top of the blackhead. The moment the pore contents re-oxidise (within days), the blackhead reappears. They don't address the cause of congestion and can damage skin around the pores with repeated use.
Replace both with salicylic acid and AHAs. They do the job chemically, without the damage.
Forty years of personal experience and thirty years of clinical practice have taught me that there are specific behaviours that keep people stuck. Most of them are things the industry has told you are good ideas.
Nobody tells you this clearly enough, so I'm going to. Acne treatment takes time - real time, not the "overnight results" time that the industry sells you. Here is what an honest clinical timeline looks like when you start a medical-grade skincare system.
Developed from forty years of wasting money on products that didn't work. These questions are what I ask myself before recommending or using anything.
People wait far too long to seek professional help for acne. The sooner you get appropriate support, the less scarring, the less cost, and the less emotional toll. Here is a clear guide to who does what.
| Professional | Best suited for |
|---|---|
| Beauty / skin therapist | Non-inflammatory and mild acne. Extractions, superficial peels, LED therapy, skincare routine advice. |
| Registered nurse | Mild to moderate acne. Medical-grade peels, deeper skin needling, LED therapy. |
| GP / Nurse Practitioner | Mild to severe acne. Prescription medicines - topical retinoids, antibiotics, the pill, spironolactone, isotretinoin referral. Professional peels and procedures. The right first call for most people. |
| Dermatologist | Moderate to severe acne, complex scarring. Isotretinoin. The specialist when GP-level care isn't sufficient. |
| Psychologist / therapist | Any time acne is affecting mental health, self-esteem, relationships, school, or work. This is not a last resort - it is appropriate, effective care and should not wait. |
Seek help immediately if any of the following apply:
The psychological impact of acne has been clinically shown to be equivalent to living with chronic asthma, diabetes, back pain, or arthritis. I don't say that to be dramatic. I say it because the people living with it know it's true, and they deserve to hear it said plainly by a clinician.
This guide gives you the framework. But your skin is individual - the triggers, the history, the barrier, what's been tried. A 15-minute consult with me is the conversation this guide is the preparation for.
Book a skin consult with Elissa$150 · Applied as credit toward the Breakout Collection · Not what I think you should buy - what your skin actually needs.